(MAXIMUM OF 50 POINTS; NO NEGATIVE MARKING, SO EDUCATED GUESSES DESIRABLE)
THE RHYTHM N BLUES ROUND (1 POINT EACH)
1. This structure has the following components: an artery and venule, nerve supply and a capsule; also within the capsules are many cholinergic muscle cells. Identify?
2. Which biological currently under early phase trials for psoriatic arthritis and FDA approved for Rheumatoid arthritis interferes with the CD28- CD80/86 T Cell Receptor (TCR) – Major Histocompatibility Complex (MHC) interaction in an immunological synapse? (Pic below)
3. Which nutrient deficiency would you need to survey for and treat if detected in management of severe childhood ichthyoses?
4. What characteristic trichological finding do you expect in patients who have a mutation in the SPINK5 gene with governs a serine protease inhibitor?
5. Identify this innocuous incidentally detected dermatosis.
THE ROCK MUSIC ROUND (2 POINTS EACH)
6. Connect the two images
7. The causative agent of Lutz‑Splendore‑de Almeida disease looks like this (see pic below). It has an appearance which uncannily resembles a Mariner’s pilot wheel. Name the causative agent.
8. A 23 year old intravenous drug user presents with the onset of purpura on the legs. Biopsy reveals vasculopathic changes with intravascular thrombi seen in superficial dermal vessels. Serum studies for cryoglobulins and Hepatitis C virus are both positive. What malignancy is this person likely to develop?
9. Characterised by recurrent mucosal involvement, HAEM has been more commonly associated with people with HLA type B15. What is HAEM?
10. What is this : cinnamic alcohol and aldehyde, hydroxycitronellal, isoeugenol, eugenol, oak moss absolute, alpha-amyl cinnamic aldehyde, geraniol?
THE HEAVY METAL ROUND (3 points each)
11. What is Bellatox therapy? Clue is pic below
12. The patient presented to the physician for the troublesome big blackhead. What is your diagnosis?
13. What is being detected by the procedure is being depicted here? (Relevant to psoriasis management)
14. This oxadiazolephenyl compound and a novel and potent inhibitor of helicase–primase is our latest weapon with in vitro antiviral activities against VZV, HSV-1 and HSV-2 that are more potent than those of acyclovir. A Japanese RCT indicated non inferiority to valacyclovir. Name the anti-viral drug.
15. Which aesthetic intervention is the most likely cause a blue nodule?
THE GRIND-CORE ROUND (5 points each x 4)
16. This syndrome is characterised by the feature below and has a 5 letter acronym as its name. It is due to anomalies of the PIK3CA gene. The features of this syndrome are a representation of common embryonic origin of lip and neck. Name the syndrome.
17. Joseph Nicolas (1868-1960) and Jean Rousset (1899-1972) described this sign first. It is also called “le signe du baldaquin” (the baldaquin sign) as it occurs in conjunction with Langer’s lines (See picture of baldaquin/canopy below). A 1956 article written by John T. Crissey gave current name of this sign. Name the sign
18. A female patient with adult acne is placed on spironolactone for her acne vulgaris. As a physician, what black box warning will you give to such a patient?
19. Connect the first two pictures to the animal in the picture below.